Non-invasive preimplantation genetic testing involves testing the spent culture medium that blastocysts were culture in for the presence of aneupolidy. Some doubt exists over whether such technology can replace trophectoderm biopsy.
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References related to niPGT-A - non-invasive preimplantation genetic tes
Shitara A, Takahashi K, Goto M, Takahashi H, Iwasawa T, Onodera Y, Makino K, Miura H, Shirasawa H, Sato W, Kumazawa Y, Terada Y. Cell-free DNA in spent culture medium effectively reflects the chromosomal status of embryos following culturing beyond implantation compared to trophectoderm biopsy. PLoS One. 2021 Feb 11,16(2):e0246438. doi: 10.1371/journal.pone.0246438
Last edited on 25/2/2021
Babariya D, Leaver M, Wells D. Divining the genetic status of embryos: consult the medium? Fertil Steril. 2019 Sep,112(3):471-473. doi: 10.1016/j.fertnstert.2019.06.012
Last edited on 16/3/2021
Hanson BM, Tao X, Hong KH, Comito CE, Pangasnan R, Seli E, Jalas C, Scott RT Jr. Noninvasive preimplantation genetic testing for aneuploidy exhibits high rates of deoxyribonucleic acid amplification failure and poor correlation with results obtained using trophectoderm biopsy. Fertil Steril. 2021 Mar 18:S0015-0282(21)00050-9. doi: 10.1016/j.fertnstert.2021.01.028
Last edited on 23/3/2021
Additional References related to niPGT-A - non-invasive preimplantation genetic tes -