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Paternal RNA and embryonic genome activation (EGA) - Course ID:50 -
SEP122+ [0]
This course explores the concept that the fertilizing spermatozoon contributes more than just its DNA but also RNA that may influence the early cleavage at the very least. The concept that the sperm may alter embryo development is in its very infancy but it is likely that it may be critical to IVF success and childhood wellbeing.
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Primary Topic 122
24/8/2020 - [Last Updated:17/8/2020]
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Created 24/8/2020
Updated 17/8/2020
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References related to Paternal RNA and embryo development -[8] [Ref=8]
Gross N, Strillacci MG, Peņagaricano F, Khatib H. Characterization and functional roles of paternal RNAs in 2-4 cell bovine embryos. Sci Rep. 2019 ID:2594
Year:, DOI:9(1):20347. Published 2019 Dec 30. doi:10.1038/s41598-019-55868-3 0 Last edited on
Castillo J, Jodar M, Oliva R. The contribution of human sperm proteins to the development and epigenome of the preimplantation embryo. Hum Reprod Update. 2018,24(5):535-555. doi:10.1093/humupd/dmy017 ID:2595
Year:0, DOI:10.1093/humupd/dmy017 0 0 Last edited on
Jodar M. Sperm and seminal plasma RNAs: what roles do they play beyond fertilization?. Reproduction. 2019,158(4):R113-R123. doi:10.1530/REP-18-0639 ID:2596
Year:0, DOI:10.1530/REP-18-0639 328 0 Last edited on
Machtinger R, Laurent LC, Baccarelli AA. Extracellular vesicles: roles in gamete maturation, fertilization and embryo implantation. Hum Reprod Update. 2016,22(2):182-193. doi:10.1093/humupd/dmv055 ID:2597
Year:0, DOI:10.1093/humupd/dmv055 0 0 Last edited on
Parrington J, Lai FA, Swann K. The soluble mammalian sperm factor protein that triggers Ca2+ oscillations in eggs: evidence for expression of mRNA(s) coding for sperm factor protein(s) in spermatogenic cells. Biol Cell. 2000,92(3-4):267-275. doi:10.1016/s0248-4900(00)01064-9 ID:2598
Year:0, DOI:10.1016/s0248-4900(00)01064-9 329 0 Last edited on
Xu H, Wang X, Wang Z, et al. MicroRNA expression profile analysis in sperm reveals hsa-mir-191 as an auspicious omen of in vitro fertilization. BMC Genomics. 2020 ID:2668
Year:True, DOI:21(1):165. Published 2020 Feb 17. doi:10.1186/s12864-020-6570-8 0 17/08/2020 9:32:31 AM Last edited on
Shi S, Shi Q, Sun Y. The effect of sperm miR-34c on human embryonic development kinetics and clinical outcomes [published online ahead of print, 2020 Jun 2]. Life Sci. 2020,256:117895. doi:10.1016/j.lfs.2020.117895 ID:2669
Year:0, DOI:10.1016/j.lfs.2020.117895 334 0 Last edited on
Cui L, Fang L, Shi B, Qiu S, Ye Y. Spermatozoa micro ribonucleic acid-34c level is correlated with intracytoplasmic sperm injection outcomes. Fertil Steril. 2015,104(2):312-7.e1. doi:10.1016/j.fertnstert.2015.05.003 ID:2670
Year:0, DOI:10.1016/j.fertnstert.2015.05.003 335 0 Last edited on

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