This course explores the concept that the fertilizing spermatozoon contributes more than just its DNA but also RNA that may influence the early cleavage at the very least. The concept that the sperm may alter embryo development is in its very infancy but it is likely that it may be critical to IVF success and childhood wellbeing.
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- [Last Updated:17/08/2020 9:36:36 AM]
List of Key Points
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Notes relating to this Course.
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References related to Paternal RNA and embryo development
Additional References related to Paternal RNA and embryo development - 
Castillo J, Jodar M, Oliva R. The contribution of human sperm proteins to the development and epigenome of the preimplantation embryo. Hum Reprod Update. 2018,24(5):535-555. doi:10.1093/humupd/dmy017
Jodar M. Sperm and seminal plasma RNAs: what roles do they play beyond fertilization?. Reproduction. 2019,158(4):R113-R123. doi:10.1530/REP-18-0639
Parrington J, Lai FA, Swann K. The soluble mammalian sperm factor protein that triggers Ca2+ oscillations in eggs: evidence for expression of mRNA(s) coding for sperm factor protein(s) in spermatogenic cells. Biol Cell. 2000,92(3-4):267-275. doi:10.1016/s0248-4900(00)01064-9
Shi S, Shi Q, Sun Y. The effect of sperm miR-34c on human embryonic development kinetics and clinical outcomes [published online ahead of print, 2020 Jun 2]. Life Sci. 2020,256:117895. doi:10.1016/j.lfs.2020.117895
Cui L, Fang L, Shi B, Qiu S, Ye Y. Spermatozoa micro ribonucleic acid-34c level is correlated with intracytoplasmic sperm injection outcomes. Fertil Steril. 2015,104(2):312-7.e1. doi:10.1016/j.fertnstert.2015.05.003