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Key Points

Sperm DNA Fragmentations Guidelines+ - Course ID:58 -
SEP133+ [0]
EXPERT RECOMMENDATIONS ON SPERM DNA FRAGMENTATION TESTING. The extensive literature search conducted in this review reveals that SDF significantly impacts male fertility and its testing in specific clinical circumstances may augment the treatment strategy resulting in better outcomes
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Primary Topic 133
11/8/2020 - [Last Updated:11/8/2020]
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Created 11/8/2020
Updated 11/8/2020
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References related to Sperm DNA Fragmentations Guidelines -[6] [Ref=6]
Agarwal A, Majzoub A, Baskaran S, et al. Sperm DNA Fragmentation: A New Guideline for Clinicians [published online ahead of print, 2020 Aug 6]. World J Mens Health. 2020,10.5534/wjmh.200128. doi:10.5534/wjmh.200128 ID:2646
Year:0, DOI:10.5534/wjmh.200128 0 8646 Last edited on
Fig. 1. Different types of DNA damage that can occur at DNA level. ID:2647
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Fig. 2. Overview of the origins of sperm DNA fragmentation (SDF). SDF result from underlying mechanisms such as defective maturation, abortive apoptosis, and oxidative stress. ID:2648
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Fig. 3. (A) Main insults that result in DNA single strand breaks are abortive topoisomerase, free radicals, and DNA ligase activity adjacent to lesion. ID:2649
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Fig. 4. Clinical algorithm to elucidate the applications of sperm DNA fragmentation (SDF) testing in clinical practice. ICSI: intracytoplasmic sperm injection. ID:2650
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Fig. 5. Strengths-Weaknesses-Opportunities-Threats (SWOT) analysis on the clinical utility of sperm DNA fragmentation (SDF) testing in specific male infertility scenario. ART: assisted reproductive techniques. ID:2651
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