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Key Points

Management of Mosaic Embryos + - Course ID:69 -
SEP144+ [830]
Chromosomal mosaicism is at high occurrence in early developmental-stage embryos, but much lower in those at prenatal stage. Trophectodermal biopsy and PGT-A has revealed a high incidence of embryos with both euploid and aneuploid cells. Whether to transfer such embryos is a current main issue for PGT-A cycles. This course explores the diagnosis and management of mosaic embryos.
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Primary Topic 144
7/1/2021 - [Last Updated:11/3/2021]
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Created 7/1/2021
Updated 11/3/2021
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174 722 SEP144+      
F82/S184 What are mosiac embryos 722/2708

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References related to Management of Mosaic Embryos -[10] [Ref=11]
Zhang YX, Chen JJ, Nabu S, et al. The Pregnancy Outcome of Mosaic Embryo Transfer: A Prospective Multicenter Study and Meta-Analysis. Genes (Basel). 2020,11(9):E973. Published 2020 Aug 21. doi:10.3390/genes11090973 ID:2708
Year:0, DOI:10.3390/genes11090973 0 8665 Last edited on
Palmerola KL, Vitez SF, Amrane S, Fischer CP, Forman EJ. Minimizing mosaicism: assessing the impact of fertilization method on rate of mosaicism after next-generation sequencing (NGS) preimplantation genetic testing for aneuploidy (PGT-A). J Assist Reprod Genet. 2019,36(1):153-157. doi:10.1007/s10815-018-1347-6 ID:2709
Year:0, DOI:10.1007/s10815-018-1347-6 0 0 Last edited on
Popovic M, Dhaenens L, Taelman J, et al. Extended in vitro culture of human embryos demonstrates the complex nature of diagnosing chromosomal mosaicism from a single trophectoderm biopsy. Hum Reprod. 2019,34(4):758-769. doi:10.1093/humrep/dez012 ID:2710
Year:0, DOI:10.1093/humrep/dez012 0 0 Last edited on
Fragouli E, Alfarawati S, Spath K, et al. Analysis of implantation and ongoing pregnancy rates following the transfer of mosaic diploid-aneuploid blastocysts. Hum Genet. 2017,136(7):805-819. doi:10.1007/s00439-017-1797-4 ID:2711
Year:0, DOI:10.1007/s00439-017-1797-4 0 0 Last edited on
Maxwell SM, Grifo JA. Should every embryo undergo preimplantation genetic testing for aneuploidy? A review of the modern approach to in vitro fertilization. Best Pract Res Clin Obstet Gynaecol. 2018,53:38-47. doi:10.1016/j.bpobgyn.2018.07.005 ID:2712
Year:0, DOI:10.1016/j.bpobgyn.2018.07.005 0 0 Last edited on
Chan YM, Li TC, Poon LCY. Impact of preimplantation genetic testing for aneuploidy on obstetrical practice. Curr Opin Obstet Gynecol. 2019,31(2):127-131. doi:10.1097/GCO.0000000000000521 ID:2713
Year:0, DOI:10.1097/GCO.0000000000000521 0 0 Last edited on
Bolton, H., Graham, S., Van der Aa, N. et al. Mouse model of chromosome mosaicism reveals lineage-specific depletion of aneuploid cells and normal developmental potential. Nat Commun 7, 11165 (2016). ID:2714
Year:0, DOI:10.1038/ncomms11165 343 0 Last edited on
Mouse model of chromosome mosaicism reveals lineage-specific depletion of aneuploid cells and normal developmental potential - Figure 7: Effects of pre-implantation chromosome mosaicism on embryo development and survival. ID:2715
Year:0, DOI:0 0 0 Last edited on
Alksere B, Grinfelde I, Kornejeva L, Dzalbs A, Vedmedovska N, Kovalova I, Conka U, Andersone S, Krasucka S, Blumberga A, Berzina D, Fodina V. The outcomes after transfers of embryos with chromosomal mosaicism: a single reproductive medicine center experience at iVF Riga clinic. Gynecol Endocrinol. 2020,36(sup1):53-57. doi: 10.1080/09513590.2020.1816719 ID:2961
Year:2020, DOI:10.1080/09513590.2020.1816719 0 8794 2020 Last edited on 13/12/2020
Gleicher N, Barad DH, Ben-Rafael Z, Glujovsky D, Mochizuki L, Modi D, Murtinger M, Patrizio P, Orvieto R, Takahashi S, Weghofer A, Ziebe S, International Do No Harm Group in IVF (IDNHG-IVF). Commentary on two recently published formal guidelines on management of "mosaic" embryos after preimplantation genetic testing for aneuploidy (PGT-A). Reprod Biol Endocrinol. 2021,19(1):23. doi:10.1186/s12958- ID:3181
Year:2021, DOI:10.1186/s12958-021-00716-1 0 8883 2021 Last edited on 20/2/2021
Viotti M, Victor AR, Barnes FL, Zouves CG, Besser AG, Grifo JA, Cheng EH, Lee MS, Horcajadas JA, Corti L, Fiorentino F, Spinella F, Minasi MG, Greco E, Munné S. Using outcome data from one thousand mosaic embryo transfers to formulate an embryo ranking system for clinical use. Fertil Steril. 2021 Mar 5:S0015-0282(20)32716-3. doi: 10.1016/j.fertnstert.2020.11.041 ID:3208
Year:2021, DOI:10.1016/j.fertnstert.2020.11.041 0 8907 2021 Last edited on 11/3/2021

Additional References related to Management of Mosaic Embryos - [1]

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