This course collates and explores publications describing the chromosomal status of embryo that have been allowed to grow and implant in vitro for an extended time (currently 5-6 days) to document the euploidy status of the ICM and trophectoderm.
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References related to PGT-A and extended culture
Shahbazi MN, Wang T, Tao X, Weatherbee BAT, Sun L, Zhan Y, Keller L, Smith GD, Pellicer A, Scott RT Jr, Seli E, Zernicka-Goetz M. Developmental potential of aneuploid human embryos cultured beyond implantation. Nat Commun. 2020 Aug 10,11(1):3987. doi: 10.1038/s41467-020-17764-7
M Popovic, L Dhaenens, J Taelman, A Dheedene, M Bialecka, P De Sutter, S M Chuva de Sousa Lopes, B Menten, B Heindryckx, Extended in vitro culture of human embryos demonstrates the complex nature of diagnosing chromosomal mosaicism from a single trophectoderm biopsy, Human Reproduction, Volume 34, Issue 4, April 2019, Pages 758–769, https://doi.org/10.1093/humrep/dez012