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List of Recent Publications. There are 16 links to this search
ID Publications  
Time-lapse imaging of cytoplasmic strings at the blastocyst stage suggests their association with spontaneous blastocoel collapse [2020]
8406 Conclusion: Time-lapse analysis of cytoplasmic strings at the blastocyst stage revealed that this morphological feature was not a negative predictor as previously reported. Although physiologically normal, at least some of the cytoplasmic strings are an artefact, possibly associated with blastocoelic collapses.
KW blastocoel collapse/blastocyst morphology/cytoplasmic strings/morphokinetics/time-lapse/

First PGT-A using human in vivo blastocysts recovered by uterine lavage: comparison with matched IVF embryo controls [2020]
8357 Uterine lavage offers a nonsurgical, minimally invasive strategy for recovery of embryos from fertile women who do not want or need IVF and who desire PGT, fertility preservation of embryos or reciprocal IVF for lesbian couples. From a research and potential clinical perspective, this technique provides a novel platform for the use of in vivo conceived human embryos as the ultimate benchmark standard for future and current ART methods.
KW in vivo/uterine lavage/blastocyst/next-generation sequencing/morphology/preimplantation genetic testing for aneuploidy/pgt-a/

Birth weight for gestational age and the risk of infertility: a Danish cohort study [2019]
8340 Men born SGA had a higher risk of infertility. Genital malformations may account for part of the observed association, but this must be explored further.
KW infertility/small for gestational age/cohort study/fetal programming/reproduction/birthweight - sga/

Does combining magnetic-activated cell sorting with density gradient or swim-up improve sperm selection? [published in 2016] [2019]
8327 Conclusions: Considering the cost/benefit ratio, MACS application together with traditional techniques may only be preferred in certain cases having higher concentrations of spermatozoa, but it does not seem to be an ideal and practical sperm selection technique for routine use.
KW sperm selection /magnetic cell sorting /dna integrity /izumo-1 /plc-z/macs/sperm selection macs/

When only one embryo is available, is it better to transfer on Day 3 or to grow on? [2019]
8288 Conclusions: These findings support Day 3 cleavage-stage embryo transfer instead of growing on to Day 4–6 for blastocyst-stage transfer when only a single embryo is available.
KW Blastocyst/Cleavage-stage embryo/Embryo transfer/IVF/Live birth/Pregnancy rate/

Embryonic aneuploidy rates are equivalent in natural cycles and gonadotropin-stimulated cycles [2019]
8263 Result(s): Aneuploidy rates were equivalent in unstimulated and stimulated IVF cycles. The prevalence of aneuploidy in natural cycles increased with the age of the female partner in a manner identical to that seen in stimulated IVF cycles. Finally, sustained implantation rates of euploid blastocysts were equivalent in natural and stimulated IVF cycles.
KW aneuploidy/stimulation/natural cycles/

Can trophectoderm RNA analysis predict human blastocyst competency? [2019]
8192 In this pilot study, we report that differential gene expression in human trophectoderm biopsies assayed by an ultra-sensitive next generation RNA sequencing strategy could predict blastocyst implantation competence....Following RNA sequencing, a total of 47 transcripts were found to be significantly differentially expressed between the trophectoderm cells from successfully implanted (competent) versus unsuccessful (incompetent) blastocysts.
KW transcriptome/rna sequencing/differential gene expression/ trophectoderm/embryo competency/embryo rna/spent culture media/trophectoderm rna analysis/

Blastomere cleavage plane orientation and the tetrahedral formation are associated with increased probability of a good-quality blastocyst for cryopre [2019]
8178 Cleavage plane orientation during the first three divisions appeared to dictate final blastomere spatial arrangement. The TET formation at the four-cell stage was predictive for embryos most likely to develop into good-quality blastocysts for cryopreservation/transfer. Morphokinetic markers of embryo potential were significantly different between TET and nTET embryos.
KW Planar embryos/time-lapse imaging/morphokinetics/spatial arrangement/multinucleation/

Use of intracytoplasmic sperm injection (ICSI) in normospermic men may result in lower clinical pregnancy and live birth rates [2019]
8166 Conclusions: Our data suggest that ICSI may be detrimental to clinical outcomes and contributes to the wider understanding of use of ICSI in normospermic men.
KW ICSI/Risks/Normospermic/

The effect of light exposure on the cleavage rate and implantation capacity of preimplantation murine embryos [2019]
8089 Highlights: (1) The implantation capacity and the immunomodulatory function of embryos exposed to white light for 25 :min or 50 :min is significantly reduced. (2) The harmful effect of white light was partly counteracted by the use of a red filter due to the increased wavelength, of the red light. (3) Based on these data, the use of red filtered light is advisable during embryo manipulation in IVF laboratories.
KW Light stress/

Time-lapse imaging of inner cell mass splitting with monochorionic triamniotic triplets after elective single embryo transfer: a case report [2019]
8072 Conclusions: Assisted reproductive techniques and in-vitro culture have been associated with an increased frequency of embryo splitting. This has been postulated to be linked to the in-vitro hatching method observed at the blastocyst stage of development. This case report highlights the need to objectively assess any splitting of the ICM, beyond standard grading of the quality of the ICM and the trophectoderm. Such assessments of ICM splitting sh
KW Inner cell mass splitting/Twinning/

Association between paternal smoking at the time of pregnancy and the semen quality in sons [2018]
7954 Conclusions: Our results suggest a negative association between paternal smoking and sperm counts in the sons, independent of the level maternal nicotine exposure during the pregnancy.
KW smoking/paternal effects/

The impact of periconceptional maternal lifestyle on clinical features and biomarkers of placental development and function: a systematic review [2018]
7943 The findings revealed that maternal smoking was associated with lower first-trimester placental vascularization flow indices/Alcohol use was associated with a lower placental weight./Adequate nutrition in the first trimester, periconceptional folic acid supplement intake and strong adherence to a Mediterranean diet, were all associated with a lower resistance of the uterine and umbilical arteries in the second and third trimester./
KW placental health/smoking/alcohol/caffeine/body weight/nutrients/ultrasound/serum biomarkers/histopathology/

Decrease in semen quality and Leydig cell function in infertile men: a longitudinal study [2018]
7917 SUMMARY ANSWER. Infertile men with severely reduced semen quality risk further deterioration of semen quality 15 years after treatment for infertility, and a lower baseline sperm concentration was associated with a more pronounced increase in LH and decrease in testosterone/LH ratio at follow-up.
KW spermatogenic failure/ FSH/inhibin B/Leydig cell/LH/testosterone/

A novel solution for freezing small numbers of spermatozoa using a sperm vitrification device [2018]
7907 The novel SpermVD is a simple efficient carrier, optimizing the protocol for freezing a small number of spermatozoa. It may allow for the routine use of frozen spermatozoa after TESE for men suffering from non-obstructive azoospermia and thus avoid repeated TESE surgeries. Furthermore, in cases of non-obstructive azoospermia, routine cryopreservation of the retrieved spermatozoa prior to the IVF cycle may avoid the risk of cycle cancelation and
KW azoospermia/SpermVD/fertilization/sperm injections, intracytoplasmic/sperm/cell freezing devices/medical/

The impact of a thin endometrial lining on fresh and frozen–thaw IVF outcomes: an analysis of over 40 000 embryo transfers [2018]
7903 Although pregnancy and live birth rates decrease with endometrial thickness, reasonable outcomes were obtained even with lower endometrial thickness measurements. These data provide valuable guidance for both physicians and patients when confronted with decisions related to a persistently thin endometrium.
KW Endometrium/Thin/

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