List of Recent Publications. There are 16 links to this search
Time-lapse imaging of cytoplasmic strings at the blastocyst stage suggests their association with spontaneous blastocoel collapse 
Conclusion: Time-lapse analysis of cytoplasmic strings at the blastocyst stage revealed that this morphological feature was not a negative predictor as previously reported. Although physiologically normal, at least some of the cytoplasmic strings are an artefact, possibly associated with blastocoelic collapses.
First PGT-A using human in vivo blastocysts recovered by uterine lavage: comparison with matched IVF embryo controls 
Uterine lavage offers a nonsurgical, minimally invasive strategy for recovery of embryos from fertile women who do not want or need IVF and who desire PGT, fertility preservation of embryos or reciprocal IVF for lesbian couples. From a research and potential clinical perspective, this technique provides a novel platform for the use of in vivo conceived human embryos as the ultimate benchmark standard for future and current ART methods.
infertility/small for gestational age/cohort study/fetal programming/reproduction/birthweight - sga/
Does combining magnetic-activated cell sorting with density gradient or swim-up improve sperm selection? [published in 2016] 
Conclusions: Considering the cost/benefit ratio, MACS application together with traditional techniques may only be preferred in certain cases having higher concentrations of spermatozoa, but it does not seem to be an ideal and practical sperm selection technique for routine use.
Embryonic aneuploidy rates are equivalent in natural cycles and gonadotropin-stimulated cycles 
Result(s): Aneuploidy rates were equivalent in unstimulated and stimulated IVF cycles. The prevalence of aneuploidy in natural cycles increased with the age of the female partner in a manner identical to that seen in stimulated IVF cycles. Finally, sustained implantation rates of euploid blastocysts were equivalent in natural and stimulated IVF cycles.
Can trophectoderm RNA analysis predict human blastocyst competency? 
In this pilot study, we report that differential gene expression in human trophectoderm biopsies assayed by an ultra-sensitive next generation RNA sequencing strategy could predict blastocyst implantation competence....Following RNA sequencing, a total of 47 transcripts were found to be significantly differentially expressed between the trophectoderm cells from successfully implanted (competent) versus unsuccessful (incompetent) blastocysts.
Blastomere cleavage plane orientation and the tetrahedral formation are associated with increased probability of a good-quality blastocyst for cryopre 
Cleavage plane orientation during the first three divisions appeared to dictate final blastomere spatial arrangement. The TET formation at the four-cell stage was predictive for embryos most likely to develop into good-quality blastocysts for cryopreservation/transfer. Morphokinetic markers of embryo potential were significantly different between TET and nTET embryos.
The effect of light exposure on the cleavage rate and implantation capacity of preimplantation murine embryos 
Highlights: (1) The implantation capacity and the immunomodulatory function of embryos exposed to white light for 25 :min or 50 :min is significantly reduced. (2) The harmful effect of white light was partly counteracted by the use of a red filter due to the increased wavelength, of the red light. (3) Based on these data, the use of red filtered light is advisable during embryo manipulation in IVF laboratories.
Time-lapse imaging of inner cell mass splitting with monochorionic triamniotic triplets after elective single embryo transfer: a case report 
Conclusions: Assisted reproductive techniques and in-vitro culture have been associated with an increased frequency of embryo splitting. This has been postulated to be linked to the in-vitro hatching method observed at the blastocyst stage of development. This case report highlights the need to objectively assess any splitting of the ICM, beyond standard grading of the quality of the ICM and the trophectoderm. Such assessments of ICM splitting sh
The impact of periconceptional maternal lifestyle on clinical features and biomarkers of placental development and function: a systematic review 
The findings revealed that maternal smoking was associated with lower first-trimester placental vascularization flow indices/Alcohol use was associated with a lower placental weight./Adequate nutrition in the first trimester, periconceptional folic acid supplement intake and strong adherence to a Mediterranean diet, were all associated with a lower resistance of the uterine and umbilical arteries in the second and third trimester./
Decrease in semen quality and Leydig cell function in infertile men: a longitudinal study 
SUMMARY ANSWER. Infertile men with severely reduced semen quality risk further deterioration of semen quality 15 years after treatment for infertility, and a lower baseline sperm concentration was associated with a more pronounced increase in LH and decrease in testosterone/LH ratio at follow-up.
A novel solution for freezing small numbers of spermatozoa using a sperm vitrification device 
The novel SpermVD is a simple efficient carrier, optimizing the protocol for freezing a small number of spermatozoa. It may allow for the routine use of frozen spermatozoa after TESE for men suffering from non-obstructive azoospermia and thus avoid repeated TESE surgeries. Furthermore, in cases of non-obstructive azoospermia, routine cryopreservation of the retrieved spermatozoa prior to the IVF cycle may avoid the risk of cycle cancelation and
The impact of a thin endometrial lining on fresh and frozen–thaw IVF outcomes: an analysis of over 40 000 embryo transfers 
Although pregnancy and live birth rates decrease with endometrial thickness, reasonable outcomes were obtained even with lower endometrial thickness measurements. These data provide valuable guidance for both physicians and patients when confronted with decisions related to a persistently thin endometrium.