Thus, GnRHa trigger already has a pivotal role, not only for the standard in vitro fertilisation (IVF) patient, but also for patient groups like oocyte donors, cancer patients, patients with poor ovarian reserve, and patients with immature oocyte syndrome and empty follicle syndrome. Herein, we discuss the importance of the GnRHa-elicited midcycle FSH surge and the potential improvement in oocyte yield and embryo competence.
Optimizing the protocol for vitrification of individual spermatozoa by adjusting equilibration time [2020]
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Post-thaw motility correlated negatively with cryoprotectant exposure time. The highest post-warming motility rate (32.1%) was observed with 8-minutes equilibration. After 10 minutes, motility rate of vitrified sperm was lower than that of bulk-freezing (31.7% x37.0%). Different cryoprotectants did not affect the results. Therefore, for vitrifying small numbers of spermatozoa, we suggest maximum equilibration time of 8-minutes to achieve maximum
Coronavirus: What we know so far about risks to pregnancy and babies. [2020]
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Pregnant people don’t seem to be at greater risk of experiencing severe covid-19, and the virus doesn’t seem to pass to fetuses, but there’s still a lot we don’t know.
IVF Worldwide Webinar Series: How an Unlikely Technology became Routine Fertility Treatment: membering the First Pioneers of IVF. Prof. Roger Gosden [2020]
Sex and suicide: The curious case of Toll-like receptors [Murine] [2020]
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During in vitro fertilisation (IVF), pharmacological activation of the murine X chromosome–encoded receptor proteins Toll-like receptor (TLR) 7 and TLR8 reportedly results in male-biased litters by selectively disrupting the motility of X-bearing sperm cells
Effects of the normal sperm morphology rate on the clinical and neonatal outcomes of conventional IVF cycles [2020]
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Total fertilisation failure was completely resolved by early rescue intracytoplasmic sperm injection. The clinical pregnancy, implantation and abortion rates were not significantly different between the two groups. Additionally, the sex, preterm birth, low birth weight, live births and birth defect rates, gestational age and birthweight of newborns were not significantly different between the two groups. Thus, normal sperm morphology rate <4% sig
Blastocysts Derived From 0PN Oocytes: Genetic And Clinical Results. [2020]
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CONCLUSION: Almost half of the 0PN blastocysts implanted (48.0%) and 13 healthy babies were born. More than three quarters (76.4%) of the 0PN blastocysts were diploid, thus ruling out the possibility of parthenogenetic activation. Our study indicated that the transfer of 0PN blastocysts is a safe, worthy option when the number of normal 2PN embryos is insufficient.
Statement of the COVID-19 FSA Response Committee (19 March 2020) [2020]
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With these recommendations, the FSA aims to provide its members (which include clinicians, scientists, nurses and counsellors) and the public evidence-based guidance that prioritises the needs and safety of patients and all staff involved in the provision of fertility care and is in line with the Australian Health Sector Emergency Response Plan for Novel Coronavirus (COVID-19).
Good practice recommendations for the use of time-lapse technology† [2020]
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This document is expected to have a significant impact on future developments of clinical embryology, considering the increasing role and impact of TLT.
Outcomes of in vitro fertilization–embryo transfer in women with diminished ovarian reserve after growth hormone pretreatment [2020]
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In women who either achieved pregnancy or utilized all the embryos resulting from the index stimulation cycle, the cumulative clinical pregnancy rate was significantly higher in women with GH compared to the control group. 4 weeks pretreatment with GH could increase ovarian response to stimulation and then improved IVF-ET outcomes in women with DOR.
Female obesity does not impact live birth rate after frozen-thawed blastocyst transfer [2020]
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Our study showed that live birth rate after frozen-thawed blastocyst transfer was not statistically different in obese and in normal-weight women. Although this needs confirmation, this suggests that the impairment of uterine receptivity observed in obese women after fresh embryo transfer might be associated with ovarian stimulation and its hormonal perturbations rather than with oocyte/embryo quality.
female obesity/fet/uterine receptivity/female obesity and fbet/
Fertilization with human sperm bound to zona pellucida by pressing onto the oocyte membrane [2020]
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This study aimed to determine whether fertilization can be obtained by assisted fusion of oocyte and sperm without breaking the oocyte membrane. - Sperm collected from the zona pellucida (ZP) were pressed onto the membrane of unfertilized oocytes at either 6 h or 24 h after IVF, a procedure that we designated as assisted sperm fusion insemination (ASFI).
zona pellucida/acrosome reaction/rescue icsi/assisted sperm fusion insemination (asfi)./
The vaginal microbiome as a tool to predict IVF success [2020]
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Summary- The local microbiota, especially the absence or presence of specific microbes, within parts of the female reproductive tract seem to be associated with the outcome of ART.
