List of Recent Publications. There are 50 links to this search
HIRA contributes to zygote formation in mice and is implicated in human 1PN zygote phenotype 
We then studied human 1PN zygotes and found that the HIRA complex was absent in 1PN zygotes that lacked the male pronucleus. This shows that the role of the HIRA complex in male pronucleus formation potentially has coherence from mice to humans.
Identifying biomarkers for predicting successful embryo implantation: applying single to multi-OMICs to improve reproductive outcome 
Here we provide a complete summary of the major achievements in human implantation research supplied by omics approaches, highlighting their potential to improve reproductive outcomes while fully elucidating the implantation mechanism.
SESSION 47: THE INVISIBLE MALE. International IVF Initiative 
“When ICSI killed Andrology” Professor Allan Pacey, "The Sixth Vital Sign: What Our Sperm Are Trying To Tell Us?" Professor Michael Eisenberg,
"The Male Reproductive Health Initiative" Professor Chris Barratt
Clinical efficacy of hyaluronate-containing embryo transfer medium in IVF/ICSI treatment cycles: a cohort study 
The use of embryo transfer (ET) medium rich in HA improves LBE (a singleton or twin live birth) regardless of the duration of exposure evaluated in this study, but does not alter gestation or birthweight (BW).
Microbial contamination in assisted reproductive technology: source, prevalence, and cost 
In conclusion, we urge clinics to more rigorously identify, register, and report contamination occurrences, and highlight the role of the study of the microbiome to improve overall results and safety of assisted reproduction.
Embryo biosensing by uterine natural killer cells determines endometrial fate decisions at implantation 
Killing of senescent decidual cells by uNK cells was also inhibited upon exposure to medium conditioned by IVF embryos that failed to implant, but not successful embryos. Embryo‐:::mediated inhibition of uNK cell activity was reversed by recombinant hyaluronidase 2 (HYAL2), which hydrolyses HMWHA. We further report a correlation between the levels of HYAL2 secretion by human blastocysts, morphological scores, and implantation potential. Take
Patient willingness, preferences and decision-making about planning for three complete cycles of IVF/ICSI treatment 
The majority of patients seem to value the opportunity to plan for multiple cycles of treatment while acknowledging both possible challenges and benefits of doing so and decisions that might need to be made in advance.
Linking stress and infertility-more than a chicken and egg conundrum 
ltimately, it remains to be determined whether negative pregnancy outcomes are impaired more by the worry of stress vs. experiencing actual stress. Nevertheless, to maximize quality of life, patients should be encouraged to understand the definition of stress—trying to control an event in which one is incapable.
ESHRE guideline: ovarian stimulation for IVF/ICSI† 
The guideline provides clinicians with clear advice on best practice in ovarian stimulation, based on the best evidence available. In addition, a list of research recommendations is provided to promote further studies in ovarian stimulation.
A brief history of oocyte cryopreservation: Arguments and facts 
However, despite the first success obtained in the 1980s with frozen oocytes, it was not until recently that notable improvements in the cryopreservation technique, thanks to the advent of vitrification, allowed a breakthrough of this fine procedure.
The Impact of the Using Culture Media Containing with Granulocyte-Macrophage Colony-Stimulating Factor on Live Birth Rates in Patients with a History 
Using GM-CSF containing culture media in patients with previous two failed IVF attempts due to embryonic developmental arrest might rectify embryological data and reproductive outcomes. To make solid conclusion further randomized controlled trial is warrant
Should we look for a low-grade threshold for blastocyst transfer? A scoping review 
This scoping review shows that LGB have similar euploidy and pregnancy success rates after implantation and have no adverse effects on pregnancy or perinatal outcomes. Evidence for pregnancy outcomes is lacking for different grades of LGB, with most studies clustering all LQB as one to compare with optimal blastocysts.
International IVF Initiative - SESSION 47: THE INVISIBLE MALE 
“When ICSI killed Andrology” Professor Allan Pacey. / "The Sixth Vital Sign: What Our Sperm Are Trying To Tell Us?" Professor Michael Eisenberg / "The Male Reproductive Health Initiative" Professor Chris Barratt
Sperm selection by rheotaxis improves sperm quality and early embryo development 
These results suggest that, in the absence of non-destructive DNA testing, the positive rheotaxis can be used to select a population of low DNA fragmentation spermatozoa with high motility, morphology and viability, leading to improved embryo developmental rates.
Commentary on two recently published formal guidelines on management of “mosaic” embryos after preimplantation genetic testing for aneuploidy (PGT-A) 
Two professional societies recently published opinions on the clinical management of "mosaic" results from preimplantation genetic testing for aneuploidy (PGT-A) in human blastocyst-stage embryos in associations with in vitro fertilization (IVF).
Your IVF Success website helps patients estimate chances of having a baby, but does it go far enough? 
So when she heard about a world-first government-funded website called Your IVF Success that launched on Monday and promises to help IVF patients estimate their chances of having a baby and compare clinics around the country, she was keen to find out more.
Methodological considerations for examining the relationship between sperm morphology and motility 
Results from studies linking morphology to motility enhance our understanding of the evolution of adaptive sperm traits and the mechanisms that regulate fertility, thus offering new insights into methods used in assisted reproductive technologies in animal science, conservation and public health.
RAC1 controls progressive movement and competitiveness of mammalian spermatozoa 
Differential RAC1 activity within a sperm population impairs the competitiveness of sperm cells expressing suboptimal RAC1 activity and thus their fertilization success, as demonstrated by t/+-derived sperm. In conjunction with t-haplotype triggered TRD, we propose that Rho GTPase signaling is essential for directing sperm towards the egg cells.
The role of ATP in the differential ability of Sr2+ to trigger Ca2+ oscillations in mouse and human eggs 
There were no major differences in the Ca2+ store content between mouse and human eggs. However, we found that the ATP concentration was consistently higher in mouse compared to human eggs. ..We suggest that human eggs may be unresponsive to Sr2+ medium because they have a lower level of cytosolic ATP.
Sonographic abnormalities in pregnancies conceived following IVF with and without preimplantation genetic testing for aneuploidy (PGT-A) 
The use of PGT-A was not associated with a difference in risk of fetal anomaly detection on a mid-trimester anatomical survey. The results of this study highlight the importance of improved patient counseling regarding the limitations of PGT-A, and of providing standard prenatal care for pregnancies conceived through ART, regardless of whether PGT-A was performed.
Lost and lonely: a qualitative study of women’s experiences of no embryo transfer owing to non-fertilization or poor embryo quality 
No embryo transfer because of failed embryo development is associated with considerable emotional suffering and the need for an early appointment with a physician to obtain information on what went wrong and new alternatives
The Incidence of Mosaicism for Individual Chromosome in Human Blastocysts Is Correlated With Chromosome Length 
Mosaicism, known as partial aneuploidies, mostly originates from mitotic errors during the post-zygotic stage: it consists of different cell lineages within a human embryo. The incidence of mosaicism has not been shown to correlate with maternal age, and its correlation with individual chromosome characteristics has not been well investigated.
Possibility of live birth in patients with low serum β:-hCG 14 :days after blastocyst transfer 
Initially low serum β:-hCG levels 14 :days after frozen blastocyst transfer indicated minimal chances of live birth. For patients having an initial β:-hCG > :58.8 mIU/ml, luteal phase support should continue.
Perspective: One-Cell and Cleavage-Stage Mouse Embryos Thrive in Hyperosmotic Oviductal Fluid Through Expression of a Glycine Neurotransmitter Transpo 
The glycine concentration in oviductal fluid can, however, rescue development in hypertonic media, so physiological conditions in vivo and in vitro likely work together to foster embryo well-being. Glycine acts on one-cell and cleavage-stage mouse embryos through the glycine-gated chloride channel, GLRA4, and uptake via the glycine neurotransmitter transporter
Six-year follow-up of children born from vitrified oocytes 
This is the first follow-up report of children born from vitrified-warmed oocytes followed by ICSI. The data suggested that the responses from the study participants on the mental and physical development of children were comparable to the data reported by the government, although more responses from patients should be collected to allow further study.
International IVF Initiative-Hosts Dr. Denny Sakkas-AI Driven Innovations in Automated Semen Analysis Building A Better Mousetrap.
Dr. Ashok Agarwal-“Nature doesn’t use a centrifuge: Microfluidics and the future of sperm preparation” Matt Feldman -Sperm DNA Fragmentation – Unlocking the secrets for the ART professionalDr. Sandro Esteves
Semen Analysis/Microfluidics/Sperm DNA Fragmentation/
'Your hopes can run away with your realistic expectations': a qualitative study of women and men's decision-making when undergoing multiple cycles of 
Factors contributing to the decision included external factors, such as their doctor's guidance, success rates, the outcomes of previous cycles and anecdotal stories of success, as well as emotional and cognitive drivers, including perception of success, hope and fear of regret.
Collecting semen samples at home for IVF/ICSI does not negatively affect the outcome of the fresh cycle 
Collecting semen samples at home has a positive effect on sperm quality (sperm concentration and motility were higher), but no significant differences in cycle outcomes are observed when these samples are used in IVF/ICSI cycles. Therefore, it is suggested that collecting semen samples at home for IVF/ICSI procedures is safe and has no negative effect on treatment outcomes.
Sperm DNA fragmentation index and high DNA stainability do not influence pregnancy success after intracytoplasmic sperm injection 
Neither DFI nor HDS at baseline influence the chances of a couple to achieve pregnancy after ICSI. Increased female age and couples who underwent more ICSI cycles were associated with lower chances of achieving pregnancy.
Birthweight and other perinatal outcomes of singletons conceived after assisted reproduction compared to natural conceived singletons in couples with 
Compared to natural conception, singletons born after intrauterine insemination with ovarian stimulation (IUI-OS) had a lower birthweight, while singletons born after IVF had comparable birthweights, in couples with unexplained subfertility.
Class action launched against Monash IVF over non-invasive embryo testing 
A heartbroken woman has launched a multi-million-dollar class action against one of Australia's leading IVF clinics, saying her chances of falling pregnant have been scuttled after a controversial genetic test labelled her embryos as "abnormal".
Endometrial thickness on the day of the LH surge: an effective predictor of pregnancy outcomes after modified natural cycle-frozen blastocyst transfer 
Decreased endometrial thickness (EMT) on the day of the LH surge is associated with older female age and a shortened proliferation phase and may be associated with low live birth and high chemical pregnancy rates.
Antioxidant pretreatment for male partner before ART for male factor subfertility: a randomized controlled trial 
SUMMARY ANSWER. There was no significant difference in clinical pregnancy rate following oral antioxidant pretreatment for male partner in couples undergoing ART for male factor subfertility compared to no pretreatment.
Women’s perceptions of fertility assessment and counselling 6 years after attending a Fertility Assessment and Counselling clinic in Denmark 
Women viewed the personalized fertility knowledge and advice they received as important aids to decision-making and they felt the benefits outweighed the risks of receiving personalized fertility information
Childless by circumstance – Using an online survey to explore the experiences of childless women who had wanted children 
The most common reason that women gave for stopping fertility treatment was due to emotional reasons (74.7%, 59/79). When asked how women felt now about their childlessness, the most common issues identified were unhappiness (85/158, 54%), acceptance (43/158, 27%) and happiness (30/158, 19%). There should be more support for unsuccessful fertility patients and other childless women, and more emphasis should be placed upon fertility education in o
Assessing Peristalsis at the Endometrial–Myometrial Junctional Zone: A Reproducible Ultrasound Technique? 
Uterine peristalsis is a reproducible observation displaying a learning curve to achieve excellent agreement. Endometrial thickness ≥:10 mm was associated with increased contraction frequency. There was no association between contraction frequency and/or directionality and clinical pregnancy rates.
Recreational and residential sun exposure and risk of endometriosis: a prospective cohort study 
SUMMARY ANSWER: Tanning bed use in early adulthood, sunscreen use and history of sunburns were associated with a greater risk of endometriosis: however, higher residential UV exposure was associated with a lower endometriosis risk.