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ID Publications  
HIRA contributes to zygote formation in mice and is implicated in human 1PN zygote phenotype [2021]
8914 This is an Open Access publication We then studied human 1PN zygotes and found that the HIRA complex was absent in 1PN zygotes that lacked the male pronucleus. This shows that the role of the HIRA complex in male pronucleus formation potentially has coherence from mice to humans.
KW Histones/1PN/

Identifying biomarkers for predicting successful embryo implantation: applying single to multi-OMICs to improve reproductive outcome [2021]
8912 This is an Open Access publication Here we provide a complete summary of the major achievements in human implantation research supplied by omics approaches, highlighting their potential to improve reproductive outcomes while fully elucidating the implantation mechanism.
KW implantation/biomarkers/genomics/epigenomics/transcriptomics/proteomics/metabolomics/

SESSION 47: THE INVISIBLE MALE. International IVF Initiative [2021]
8910 This is an Open Access publication “When ICSI killed Andrology” Professor Allan Pacey, "The Sixth Vital Sign: What Our Sperm Are Trying To Tell Us?" Professor Michael Eisenberg, "The Male Reproductive Health Initiative" Professor Chris Barratt
KW Male Infertility/Video/

Clinical efficacy of hyaluronate-containing embryo transfer medium in IVF/ICSI treatment cycles: a cohort study [2021]
8908 This is an Open Access publication The use of embryo transfer (ET) medium rich in HA improves LBE (a singleton or twin live birth) regardless of the duration of exposure evaluated in this study, but does not alter gestation or birthweight (BW).
KW hyaluronate/

Microbial contamination in assisted reproductive technology: source, prevalence, and cost [2021]
8906 This is an Open Access publication In conclusion, we urge clinics to more rigorously identify, register, and report contamination occurrences, and highlight the role of the study of the microbiome to improve overall results and safety of assisted reproduction.
KW Microbial contamination/Microbiota/Semen/

Embryo biosensing by uterine natural killer cells determines endometrial fate decisions at implantation [2021]
8905 This is an Open Access publication Killing of senescent decidual cells by uNK cells was also inhibited upon exposure to medium conditioned by IVF embryos that failed to implant, but not successful embryos. Embryo‐:::mediated inhibition of uNK cell activity was reversed by recombinant hyaluronidase 2 (HYAL2), which hydrolyses HMWHA. We further report a correlation between the levels of HYAL2 secretion by human blastocysts, morphological scores, and implantation potential. Take
KW HYLA2/biosensing/natural Killer cells/Implantation/Secretome/

Shanna Swan: 'Most couples may have to use assisted reproduction by 2045' [2021]
8904 This is an Open Access publication The professor of environmental medicine explains how chemicals in plastics are causing our fertility to decline – and what we can do about it
KW Phthalates/Bisphenol A (BPA)/

Patient willingness, preferences and decision-making about planning for three complete cycles of IVF/ICSI treatment [2021]
8903 This is an Open Access publication The majority of patients seem to value the opportunity to plan for multiple cycles of treatment while acknowledging both possible challenges and benefits of doing so and decisions that might need to be made in advance.
KW multiple cycles/decision-making/

Association between serum oestradiol level on the hCG administration day and neonatal birthweight after IVF-ET among 3659 singleton live births [2021]
8901 This is an Open Access publication Our observations suggest that the hyper-oestrogenic milieu during COS does not seem to have adverse effects on the birthweight of offspring after IVF
KW Maximium oestradiol/neonatal birthweight/

Biological Impact of Unilateral Oophorectomy: Does the Number of Ovaries Really Matter? [2021]
8900 This is an Open Access publication At present, patients who undergo UO can be reassured with regard to their reproductive potential and their age at onset of menopaus
KW Unilateral Oophorectomy

Linking stress and infertility-more than a chicken and egg conundrum [2021]
8898 This is an Open Access publication ltimately, it remains to be determined whether negative pregnancy outcomes are impaired more by the worry of stress vs. experiencing actual stress. Nevertheless, to maximize quality of life, patients should be encouraged to understand the definition of stress—trying to control an event in which one is incapable.
KW Cognitive behavior therapy/Ghrelin/IVF/Infertility/Psychological support/Psychotherapy/Stress/

ESHRE guideline: ovarian stimulation for IVF/ICSI† [2021]
8897 This is an Open Access publication The guideline provides clinicians with clear advice on best practice in ovarian stimulation, based on the best evidence available. In addition, a list of research recommendations is provided to promote further studies in ovarian stimulation.
KW Guidelines/Stimulation/OHSS/

Overweight and obesity significantly reduce pregnancy, implantation, and live birth rates in women undergoing In Vitro Fertilization procedures [2021]
8896 This is an Open Access publication Our data shows that an increased BMI affects embryo development and significantly reduces the pregnancy, implantation and live birth rates
KW weight/BMI/Body mass index/

A brief history of oocyte cryopreservation: Arguments and facts [2021]
8894 This is an Open Access publication However, despite the first success obtained in the 1980s with frozen oocytes, it was not until recently that notable improvements in the cryopreservation technique, thanks to the advent of vitrification, allowed a breakthrough of this fine procedure.
KW Oocyte Cryopreservation/

The Impact of the Using Culture Media Containing with Granulocyte-Macrophage Colony-Stimulating Factor on Live Birth Rates in Patients with a History [2021]
8889 This is an Open Access publication Using GM-CSF containing culture media in patients with previous two failed IVF attempts due to embryonic developmental arrest might rectify embryological data and reproductive outcomes. To make solid conclusion further randomized controlled trial is warrant
KW GM-CSF/ failed IVF/

Should we look for a low-grade threshold for blastocyst transfer? A scoping review [2021]
8888 This is an Open Access publication This scoping review shows that LGB have similar euploidy and pregnancy success rates after implantation and have no adverse effects on pregnancy or perinatal outcomes. Evidence for pregnancy outcomes is lacking for different grades of LGB, with most studies clustering all LQB as one to compare with optimal blastocysts.
KW low grade blastocyts/minimium standards/

Cell-free DNA in spent culture medium effectively reflects the chromosomal status of embryos following culturing beyond implantation compared to troph [2021]
8887 This is an Open Access publication The concordance rate between the niPGT-A and outgrowth samples was 9/16 (56.3%), and the concordance rate between the PGT-A and outgrowth samples was 7/16 (43.8%).
KW niPGT-A/cfDNA/Outgrowth/blastocyst/

International IVF Initiative - SESSION 47: THE INVISIBLE MALE [2021]
8886 This is an Open Access publication “When ICSI killed Andrology” Professor Allan Pacey. / "The Sixth Vital Sign: What Our Sperm Are Trying To Tell Us?" Professor Michael Eisenberg / "The Male Reproductive Health Initiative" Professor Chris Barratt
KW Video/male health/

Sperm selection by rheotaxis improves sperm quality and early embryo development [2021]
8884 This is an Open Access publication These results suggest that, in the absence of non-destructive DNA testing, the positive rheotaxis can be used to select a population of low DNA fragmentation spermatozoa with high motility, morphology and viability, leading to improved embryo developmental rates.
KW rheotaxis/sperm motility/sperm seleciton/

Commentary on two recently published formal guidelines on management of “mosaic” embryos after preimplantation genetic testing for aneuploidy (PGT-A) [2021]
8883 This is an Open Access publication Two professional societies recently published opinions on the clinical management of "mosaic" results from preimplantation genetic testing for aneuploidy (PGT-A) in human blastocyst-stage embryos in associations with in vitro fertilization (IVF).
KW mosaicism/

Your IVF Success website helps patients estimate chances of having a baby, but does it go far enough? [2021]
8880 This is an Open Access publication So when she heard about a world-first government-funded website called Your IVF Success that launched on Monday and promises to help IVF patients estimate their chances of having a baby and compare clinics around the country, she was keen to find out more.
KW Website/

Methodological considerations for examining the relationship between sperm morphology and motility [2021]
8874 This is an Open Access publication Results from studies linking morphology to motility enhance our understanding of the evolution of adaptive sperm traits and the mechanisms that regulate fertility, thus offering new insights into methods used in assisted reproductive technologies in animal science, conservation and public health.
KW Sperm motility/Sperm morphology/

RAC1 controls progressive movement and competitiveness of mammalian spermatozoa [2021]
8873 This is an Open Access publication Differential RAC1 activity within a sperm population impairs the competitiveness of sperm cells expressing suboptimal RAC1 activity and thus their fertilization success, as demonstrated by t/+-derived sperm. In conjunction with t-haplotype triggered TRD, we propose that Rho GTPase signaling is essential for directing sperm towards the egg cells.
KW Research/sperm motility/RAC1/

The role of ATP in the differential ability of Sr2+ to trigger Ca2+ oscillations in mouse and human eggs [2021]
8869 This is an Open Access publication There were no major differences in the Ca2+ store content between mouse and human eggs. However, we found that the ATP concentration was consistently higher in mouse compared to human eggs. ..We suggest that human eggs may be unresponsive to Sr2+ medium because they have a lower level of cytosolic ATP.
KW PLCz/oocyte/ATP/

Semen impairment and occurrence of SARS-CoV-2 virus in semen after recovery from COVID-19 [2021]
8868 This is an Open Access publication SUMMARY ANSWER Twenty-five percent of the men with recent SARS-Cov-2 infections and proven healing were oligo-crypto-azoospermic, despite the absence of virus RNA in semen
KW COVID-19/semen prrfile/

Sonographic abnormalities in pregnancies conceived following IVF with and without preimplantation genetic testing for aneuploidy (PGT-A) [2021]
8866 This is an Open Access publication The use of PGT-A was not associated with a difference in risk of fetal anomaly detection on a mid-trimester anatomical survey. The results of this study highlight the importance of improved patient counseling regarding the limitations of PGT-A, and of providing standard prenatal care for pregnancies conceived through ART, regardless of whether PGT-A was performed.
KW Fetal anomalies/PGT-A/

How Technology is Changing the Ways We Create Children with author Dr. Robert L. Klitzman [2021]
8865 This is an Open Access publication ASRM Today: Book Review of Designing Babies: How Technology is Changing the Ways We Create Children with author Dr. Robert L. Klitzman
KW Podcast/

ANZSREI consensus statement on elective oocyte cryopreservation [2021]
8864 This is an Open Access publication Oocyte cryopreservation has the potential to improve cumulative live birth outcomes for women. Implementation of this guideline should facilitate an optimal approach for providing care.
KW social egg freezing/elective oocyte cryopreservation/oocyte/freezing/

ASRM Today: Oocyte Cryopreservation with Dr. Jennifer Mersereau and Dr. Suleena Kalra [Podast] [2021]
8860 This is an Open Access publication In this episode, we have Dr. Jennifer Mersereau and Dr. Suleena Kaira on the show to discuss the update document on Oocyte Cryopreservation.
KW Oocyte Cryopreservation/podcast/

Lost and lonely: a qualitative study of women’s experiences of no embryo transfer owing to non-fertilization or poor embryo quality [2021]
8858 This is an Open Access publication No embryo transfer because of failed embryo development is associated with considerable emotional suffering and the need for an early appointment with a physician to obtain information on what went wrong and new alternatives
KW emotional stress/no embryo transfer/psychological support/

The Incidence of Mosaicism for Individual Chromosome in Human Blastocysts Is Correlated With Chromosome Length [2021]
8856 This is an Open Access publication Mosaicism, known as partial aneuploidies, mostly originates from mitotic errors during the post-zygotic stage: it consists of different cell lineages within a human embryo. The incidence of mosaicism has not been shown to correlate with maternal age, and its correlation with individual chromosome characteristics has not been well investigated.
KW mosaicism/

Influence of age, stigma and social support on male temporary ejaculation failure on IVF oocyte retrieval day [2021]
8850 This is an Open Access publication The results obtained in this study have indicated that age and stigma are independent risk factors for male TEF, while family support is a protective factor of TEF
KW Temporary ejaculation failure/

Possibility of live birth in patients with low serum β:-hCG 14 :days after blastocyst transfer [2021]
8849 This is an Open Access publication Initially low serum β:-hCG levels 14 :days after frozen blastocyst transfer indicated minimal chances of live birth. For patients having an initial β:-hCG > :58.8 mIU/ml, luteal phase support should continue.
KW Human chorionic gonadotropin/hCG/

Perspective: One-Cell and Cleavage-Stage Mouse Embryos Thrive in Hyperosmotic Oviductal Fluid Through Expression of a Glycine Neurotransmitter Transpo [2021]
8845 This is an Open Access publication The glycine concentration in oviductal fluid can, however, rescue development in hypertonic media, so physiological conditions in vivo and in vitro likely work together to foster embryo well-being. Glycine acts on one-cell and cleavage-stage mouse embryos through the glycine-gated chloride channel, GLRA4, and uptake via the glycine neurotransmitter transporter
KW oviductal fluid/glycine/

Six-year follow-up of children born from vitrified oocytes [2021]
8840 This is an Open Access publication This is the first follow-up report of children born from vitrified-warmed oocytes followed by ICSI. The data suggested that the responses from the study participants on the mental and physical development of children were comparable to the data reported by the government, although more responses from patients should be collected to allow further study.
KW Oocyte vitrification/IVF Chlidren/

Moving Sperm Forward [2021]
8837 This is an Open Access publication International IVF Initiative-Hosts Dr. Denny Sakkas-AI Driven Innovations in Automated Semen Analysis Building A Better Mousetrap. Dr. Ashok Agarwal-“Nature doesn’t use a centrifuge: Microfluidics and the future of sperm preparation” Matt Feldman -Sperm DNA Fragmentation – Unlocking the secrets for the ART professionalDr. Sandro Esteves
KW Semen Analysis/Microfluidics/Sperm DNA Fragmentation/

'Your hopes can run away with your realistic expectations': a qualitative study of women and men's decision-making when undergoing multiple cycles of [2021]
8836 This is an Open Access publication Factors contributing to the decision included external factors, such as their doctor's guidance, success rates, the outcomes of previous cycles and anecdotal stories of success, as well as emotional and cognitive drivers, including perception of success, hope and fear of regret.
KW decision-making/psychological wellbeing./

Collecting semen samples at home for IVF/ICSI does not negatively affect the outcome of the fresh cycle [2021]
8834 This is an Open Access publication Collecting semen samples at home has a positive effect on sperm quality (sperm concentration and motility were higher), but no significant differences in cycle outcomes are observed when these samples are used in IVF/ICSI cycles. Therefore, it is suggested that collecting semen samples at home for IVF/ICSI procedures is safe and has no negative effect on treatment outcomes.
KW Semen collection/

The ovarian sensitivity index is predictive of live birth chances after IVF in infertile patients [2021]
8832 This is an Open Access publication The OSI is predictive of pregnancy and live birth in older women with a more unfavorable prognosis undergoing FSH/hMG stimulation for IVF.
KW ovarian response/ovarian sensitivity index/soi/

The effectiveness of a collaborative infertility counseling (CIC) on pregnancy outcome in women undergoing in vitro fertilization: a randomized trial [2021]
8831 This is an Open Access publication Overall the findings indicated that the collaborative infertility counseling did not improve treatment success in infertile women undergoing in vitro fertilization.
KW Counselling/

Sperm DNA fragmentation index and high DNA stainability do not influence pregnancy success after intracytoplasmic sperm injection [2020]
8825 This is an Open Access publication Neither DFI nor HDS at baseline influence the chances of a couple to achieve pregnancy after ICSI. Increased female age and couples who underwent more ICSI cycles were associated with lower chances of achieving pregnancy.
KW Sperm DNA Fragmentation/outcome/

Birthweight and other perinatal outcomes of singletons conceived after assisted reproduction compared to natural conceived singletons in couples with [2020]
8822 This is an Open Access publication Compared to natural conception, singletons born after intrauterine insemination with ovarian stimulation (IUI-OS) had a lower birthweight, while singletons born after IVF had comparable birthweights, in couples with unexplained subfertility.
KW perinatal outcomes/birthweight/unexplained subfertility/

Class action launched against Monash IVF over non-invasive embryo testing [2020]
8820 This is an Open Access publication A heartbroken woman has launched a multi-million-dollar class action against one of Australia's leading IVF clinics, saying her chances of falling pregnant have been scuttled after a controversial genetic test labelled her embryos as "abnormal".
KW niPGT-A/Non-invasive preimplantation genetic testing/Legal/

Endometrial thickness on the day of the LH surge: an effective predictor of pregnancy outcomes after modified natural cycle-frozen blastocyst transfer [2020]
8819 This is an Open Access publication Decreased endometrial thickness (EMT) on the day of the LH surge is associated with older female age and a shortened proliferation phase and may be associated with low live birth and high chemical pregnancy rates.
KW endometrial thickness/natural cycle/

Antioxidant pretreatment for male partner before ART for male factor subfertility: a randomized controlled trial [2020]
8818 This is an Open Access publication SUMMARY ANSWER. There was no significant difference in clinical pregnancy rate following oral antioxidant pretreatment for male partner in couples undergoing ART for male factor subfertility compared to no pretreatment.
KW antioxidants/male subfertility/

Women’s perceptions of fertility assessment and counselling 6 years after attending a Fertility Assessment and Counselling clinic in Denmark [2020]
8817 This is an Open Access publication Women viewed the personalized fertility knowledge and advice they received as important aids to decision-making and they felt the benefits outweighed the risks of receiving personalized fertility information
KW counselling/qualitative research/reproductive decision-making/

Ovarian Club XVI - Asia, which took place online, December 12, 2020. [2020]
8816 This is an Open Access publication Recordings are now available! - Click here to view the on-demand recordings from the Ovarian Club XVI - Asia, which took place online, December 12, 2020.
KW conference /videos/

Childless by circumstance – Using an online survey to explore the experiences of childless women who had wanted children [2020]
8813 This is an Open Access publication The most common reason that women gave for stopping fertility treatment was due to emotional reasons (74.7%, 59/79). When asked how women felt now about their childlessness, the most common issues identified were unhappiness (85/158, 54%), acceptance (43/158, 27%) and happiness (30/158, 19%). There should be more support for unsuccessful fertility patients and other childless women, and more emphasis should be placed upon fertility education in o
KW childless/childlessness/

Assessing Peristalsis at the Endometrial–Myometrial Junctional Zone: A Reproducible Ultrasound Technique? [2020]
8808 This is an Open Access publication Uterine peristalsis is a reproducible observation displaying a learning curve to achieve excellent agreement. Endometrial thickness ≥:10 mm was associated with increased contraction frequency. There was no association between contraction frequency and/or directionality and clinical pregnancy rates.
KW Uterine Peristalsis/Junctional Zone/Endometrial Thickness/

Recreational and residential sun exposure and risk of endometriosis: a prospective cohort study [2020]
8807 This is an Open Access publication SUMMARY ANSWER: Tanning bed use in early adulthood, sunscreen use and history of sunburns were associated with a greater risk of endometriosis: however, higher residential UV exposure was associated with a lower endometriosis risk.
KW Endometriosis/epidemiology/sunburn/sun exposure/

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