Kong CS, Ordoņez AA, Turner S, Tremaine T, Muter J, Lucas ES, Salisbury E, Vassena R, Tiscornia G, Fouladi-Nashta AA, Hartshorne G, Brosens JJ, Brighton PJ. Embryo biosensing by uterine natural killer cells determines endometrial fate decisions at implantation. FASEB J. 2021 Apr,35(4):e21336. doi: 10.1096/fj.202002217R
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Embryo biosensing by uterine natural killer cells determines endometrial fate decisions at implantation
Killing of senescent decidual cells by uNK cells was also inhibited upon exposure to medium conditioned by IVF embryos that failed to implant, but not successful embryos. Embryo‐:::mediated inhibition of uNK cell activity was reversed by recombinant hyaluronidase 2 (HYAL2), which hydrolyses HMWHA. We further report a correlation between the levels of HYAL2 secretion by human blastocysts, morphological scores, and implantation potential. Take