- Created on 8/02/2020 5:06:18 PM
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Shooting STAR: re-interpreting the data from the “Single Embryo Transfer of Euploid Embryo” randomized clinical trial
According to our model, the STAR trial has demonstrated that transferring only blastocysts classified as “euploid” after PGT-A test leads to a reduction from 82.2 % to 50.0 % of the live birth rate for competent embryos, thus supporting the idea that PGT-A is associated with some embryo wastage.
Prospective randomized multicentre comparison on sibling oocytes comparing G-Series media system with antioxidants versus standard G-Series media syst
Conclusions. The presence of antioxidants during IVF and embryo culture for patients 35 to 40 years resulted in a significant increase in implantation and pregnancy rate. Supplementation of antioxidants to IVF and culture media may therefore improve the viability of human embryos in ART, plausibly through the reduction of oxidative stress.
The BlastGen study: A randomised controlled trial of GM-CSF supplemented blastocyst media.
This study demonstrated a significant reduction in Day 5 embryo outcome parameters using Embryogen®/BlastGen™ compared to standard medium, and insufficient evidence of a difference in pregnancy outcomes. Taking into consideration the small samples size, study limitations, and strict inclusion criteria of this single-centred study, further research is necessary to determine the efficacy of Embryogen®/BlastGen™ medium in couples undergoing IVF/ICSI
Mechanical stimulation of embryos in surrounding culture fluid induces and amplifies the cell to cell communication and leads to positive effects on embryo development and quality. An additional effect of micro-vibrations can be found in the continuous refreshment of the medium surrounding the embryo.
“Naturalization” of Routine Assisted Reproductive Technologies by In Vitro Culture of Embryos with Microvibration: Sex Ratio, Body Length, and Weight
The proportion of males at birth was significantly associated with mode of in vitro culture of embryos only among women aged 40 years and older...It was concluded that birth weight of infants was positively associated with mode of in vitro culture of embryos under microvibration among women of all age groups.
Aseptic Technology for Cryoprotectant-Free Vitrification of
Human Spermatozoa by Direct Dropping into Clean Liquid Air:
Apoptosis, Necrosis, Motilit
It is concluded that cryoprotectant-free vitrification by the direct dropping of human spermatozoa in a clean cooling agent (liquid air) is a good alternative to the use of nonsterile liquid nitrogen and can be used to cool cells while minimising the risk of microbial contamination.
Conventional freezing vs. cryoprotectant-free vitrification of epididymal (MESA) and testicular (TESE) spermatozoa: Three live births
This is the first report of full-term pregnancies and babies born after ICSI with epididymal and testicular spermatozoa vitrified without cryoprotectants. In conclusion, cryoprotectant-free vitrification can be successfully applied for the cryopreservation of motile TESE- and MESA-spermatozoa.
The KidscoreTM D5 algorithm as an additional tool to morphological assessment and PGT-A in embryo selection: a time-lapse study. [PDF Download]
CONCLUSION.Embryo selection based on the KS5 algorithm score improved the implantation rates of single euploid blastocyst transfers. Furthermore, embryos with the highest KS5 score had a higher probability of being euploid and implanting.
Performance of Day 5 KIDScore™ morphokinetic prediction models of implantation and live birth after single blastocyst transfer
KIDScore™ Day 5 predictive models are significantly associated with implantation rates after day 5 single blastocyst transfer. However, their predictive performance remains perfectible. The use of these predictive models holds promises as decision-making tools to help the embryologist select the best embryo, ultimately facilitating the implementation of SET policy. However, embryologists’ expertise remains absolutely necessary to make the final d